| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM2P06 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | WB: 1:500-1:1000 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | CAMK2A |
| Gene ID: | 815 |
| Uniprot ID: | KCC2A_HUMAN |
| Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway. Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit AlphaCam Kinase Ii Subunit AlphaCamk-Ii Subunit Alpha |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-3371571Reactome: R-HSA-399719Reactome: R-HSA-4086398Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5576892Reactome: R-HSA-5578775Reactome: R-HSA-5673000Reactome: R-HSA-5673001Reactome: R-HSA-6802946Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-877300Reactome: R-HSA-9022692Reactome: R-HSA-936837Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | SynapsePostsynaptic DensityCell ProjectionDendritic SpineDendritePostsynaptic Lipid Rafts |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha antibodyAnti-Cam Kinase Ii Subunit Alpha antibodyAnti-Camk-Ii Subunit Alpha antibodyAnti-CAMK2A antibodyAnti-CAMKA antibodyAnti-KIAA0968 antibody |
Information sourced from Uniprot.org