Anti-RD3 antibody (126-176 aa) (STJ196042)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human RD3 at the amino acid range 126-176
General Information
| Short Description | Rabbit polyclonal anti-Protein RD3 (126-176 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RD3 |
| Gene ID | 343035 |
| Uniprot ID | RD3_HUMAN |
| Immunogen | Synthesized peptide derived from the human RD3 at the amino acid range 126-176 |
| Immunogen Region | 126-176 aa |
| Specificity | This antibody detects endogenous levels of RD3 at Human/Mouse |
Additional Info
| Function | Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina. |
| Protein Name | Protein Rd3Retinal Degeneration Protein 3 |
| Database Links | |
| Cellular Localisation | Cell ProjectionCiliumPhotoreceptor Outer SegmentPhotoreceptor Inner SegmentEndosomeNucleusCytoplasmPerinuclear RegionColocalizes With Gucy2e And Gucy2f In Rods And Cones PhotoreceptorsColocalizes With Guk1 In Photoreceptor Inner Segments And To A Lesser Extent In The Outer Plexiform LayerStrong Dot-Like Perinuclear Staining In The Epithelial Cells |
| Alternative Antibody Names | Anti-Protein Rd3 antibodyAnti-Retinal Degeneration Protein 3 antibodyAnti-RD3 antibodyAnti-C1orf36 antibody |
Information sourced from Uniprot.org