Anti-RCOR1 antibody (1-100) [S2MR] (STJ11101902)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal CoREST (1-100) antibody for use in WB, IHC-P, IP, ELISA and ChIP in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP/ELISA/ChIP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:200-1:800IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RCOR1 |
| Gene ID | 23186 |
| Uniprot ID | RCOR1_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MPAMVEKGPEVSGKRRGRNN AAASASAAAASAAASAACAS PAATAASGAAASSASAAAAS AAAAPNNGQNKSLAAAAPNG NSSSNSWEEGSSGSSSDEEH |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CoREST/RCOR1 (Q9UKL0). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated by HSV-1 protein kinases in case of infection. |
| Function | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. |
| Protein Name | Rest Corepressor 1Protein Corest |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusUpon Infection By Hsv-1It Is Partially Translocated Into The Cytoplasm In An Hsv-1-Dependent Manner |
| Alternative Antibody Names | Anti-Rest Corepressor 1 antibodyAnti-Protein Corest antibodyAnti-RCOR1 antibodyAnti-KIAA0071 antibodyAnti-RCOR antibody |
Information sourced from Uniprot.org