Anti-RBM39 antibody (400-508) (STJ118205)

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STJ118205
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RBM39
Gene ID: 9584
Uniprot ID: RBM39_HUMAN
Immunogen Region: 400-508
Specificity: A synthetic peptide corresponding to a sequence within amino acids 400-508 of human RBM39 (NP_001229528.1).
Immunogen Sequence: ATQCFQLSNMFNPQTEEEVG WDTEIKDDVIEECNKHGGVI HIYVDKNSAQGNVYVKCPSI AAAIAAVNALHGRWFAGKMI TAAYVPLPTYHNLFPDSMTA TQLLVPSRR
Tissue Specificity Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain. Expressed at intermediate level in kidney, liver and heart.
Post Translational Modifications Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex. RBM39 degradation results in splicing defects and death in cancer cell lines. Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39.
Function RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity.
Protein Name Rna-Binding Protein 39
Caper Alpha
Caperalpha
Hepatocellular Carcinoma Protein 1
Rna-Binding Motif Protein 39
Rna-Binding Region-Containing Protein 2
Splicing Factor Hcc1
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus Speckle
Concentrated In Nuclear Speckles
Colocalizes With The Core Spliceosomal Snrnp Proteins
Alternative Antibody Names Anti-Rna-Binding Protein 39 antibody
Anti-Caper Alpha antibody
Anti-Caperalpha antibody
Anti-Hepatocellular Carcinoma Protein 1 antibody
Anti-Rna-Binding Motif Protein 39 antibody
Anti-Rna-Binding Region-Containing Protein 2 antibody
Anti-Splicing Factor Hcc1 antibody
Anti-RBM39 antibody
Anti-HCC1 antibody
Anti-RNPC2 antibody

Information sourced from Uniprot.org