Anti-RASIP1/RAIN antibody (C-Term) (STJ70569)

SKU:
STJ70569-100

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Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-RASIP1/RAIN (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-3.75µg/ml
ELISA-antibody detection limit dilution 1:8000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: RASIP1
Gene ID: 54922
Uniprot ID: RAIN_HUMAN
Immunogen Region: C-Term
Accession Number: NP_060275.2
Immunogen Sequence: CANYRHGPPVATSP
Function Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
Protein Name Ras-Interacting Protein 1
Rain
Cellular Localisation Cytoplasm
Perinuclear Region
Golgi Apparatus
Golgi Stack
Associated With Perinuclear Vesicles
Is Recruited To Golgi Stacks By Activated Hras
Alternative Antibody Names Anti-Ras-Interacting Protein 1 antibody
Anti-Rain antibody
Anti-RASIP1 antibody

Information sourced from Uniprot.org