Anti-RASIP1 antibody (635-785) (STJ11100420)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RASIP1 (635-785) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RASIP1 |
| Gene ID | 54922 |
| Uniprot ID | RAIN_HUMAN |
| Immunogen Region | 635-785 |
| Immunogen Sequence | TPEAVSVELRPLMLWMANTT ELLSFVQEKVLEMEKEADQE DPQLCNDLELCDEAMALLDE VIMCTFQQSVYYLTKTLYST LPALLDSNPFTAGAELPGPG AELGAMPPGLRPTLGVFQAA LELTSQCELHPDLVSQTFGY LFFFSNASLLN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 635-785 of human RASIP1 (Q5U651). |
Additional Info
| Tissue Specificity | Highly expressed in heart. Detected at lower levels in placenta and pancreas. |
| Function | Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. |
| Protein Name | Ras-Interacting Protein 1Rain |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionGolgi ApparatusGolgi StackAssociated With Perinuclear VesiclesIs Recruited To Golgi Stacks By Activated Hras |
| Alternative Antibody Names | Anti-Ras-Interacting Protein 1 antibodyAnti-Rain antibodyAnti-RASIP1 antibody |
Information sourced from Uniprot.org