| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RASGRP1 |
| Gene ID: |
10125 |
| Uniprot ID: |
GRP1_HUMAN |
| Immunogen Region: |
598-797 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 598-797 of human RASGRP1 (NP_005730.2). |
| Immunogen Sequence: |
PVAPTENNTSVGPVSNLCSL GAKDLLHAPEEGPFTFPNGE AVEHGEESKDRTIMLMGVSS QKISLRLKRAVAHKATQTES QPWIGSEGPSGPFVLSSPRK TAQDTLYVLPSPTSPCPSPV LVRKRAFVKWENKDSLIKSK EELRHLRLPTYQELEQEINT LKADNDALKIQLKYAQKKIE SLQLEKSNHVLAQMEQGDCS |
| Tissue Specificity | Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level). |
| Function | Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. |
| Protein Name | Ras Guanyl-Releasing Protein 1Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor IiCaldag-GefiiRas Guanyl-Releasing Protein |
| Database Links | Reactome: R-HSA-114508Reactome: R-HSA-1169092Reactome: R-HSA-2871837Reactome: R-HSA-354192Reactome: R-HSA-392517Reactome: R-HSA-5673001 |
| Cellular Localisation | CytoplasmCytosolCell MembranePeripheral Membrane ProteinGolgi Apparatus MembraneEndoplasmic Reticulum MembraneFound Both In The Cytosol And Associated With MembranesRelocalization To The Cell Membrane Upon Activation Is F-Actin-DependentTranslocates To The Golgi In Response To Phorbol Ester Or Nerve Growth FactorLocalizes To Somata And Dendrites But Not To Axons Of Hippocampal Pyramidal Cells |
| Alternative Antibody Names | Anti-Ras Guanyl-Releasing Protein 1 antibodyAnti-Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor Ii antibodyAnti-Caldag-Gefii antibodyAnti-Ras Guanyl-Releasing Protein antibodyAnti-RASGRP1 antibodyAnti-RASGRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
