| Tissue Specificity | Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level). |
| Function | Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. |
| Protein Name | Ras Guanyl-Releasing Protein 1Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor IiCaldag-GefiiRas Guanyl-Releasing Protein |
| Database Links | Reactome: R-HSA-114508Reactome: R-HSA-1169092Reactome: R-HSA-2871837Reactome: R-HSA-354192Reactome: R-HSA-392517Reactome: R-HSA-5673001 |
| Cellular Localisation | CytoplasmCytosolCell MembranePeripheral Membrane ProteinGolgi Apparatus MembraneEndoplasmic Reticulum MembraneFound Both In The Cytosol And Associated With MembranesRelocalization To The Cell Membrane Upon Activation Is F-Actin-DependentTranslocates To The Golgi In Response To Phorbol Ester Or Nerve Growth FactorLocalizes To Somata And Dendrites But Not To Axons Of Hippocampal Pyramidal Cells |
| Alternative Antibody Names | Anti-Ras Guanyl-Releasing Protein 1 antibodyAnti-Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor Ii antibodyAnti-Caldag-Gefii antibodyAnti-Ras Guanyl-Releasing Protein antibodyAnti-RASGRP1 antibodyAnti-RASGRP antibody |
Information sourced from Uniprot.org
