| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAPGEF6 |
| Gene ID: | 51735 |
| Uniprot ID: | RPGF6_HUMAN |
| Immunogen Region: | 145-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 145-240 of human RAPGEF6 (NP_001157858). |
| Immunogen Sequence: | INYKGERQTITDDVEVNSYL SLPADLTKMHLTENPHPQVT HVSSSQSGCSIASDSGSSSL SDIYQATESEVGDVDLTRLP EGPVDSEDDEEEDEEI |
| Tissue Specificity | Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. |
| Function | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. |
| Protein Name | Rap Guanine Nucleotide Exchange Factor 6Pdz Domain-Containing Guanine Nucleotide Exchange Factor 2Pdz-Gef2Ra-Gef-2 |
| Cellular Localisation | CytoplasmCell MembraneUpon Binding To M-RasIt Translocates To The Plasma Membrane |
| Alternative Antibody Names | Anti-Rap Guanine Nucleotide Exchange Factor 6 antibodyAnti-Pdz Domain-Containing Guanine Nucleotide Exchange Factor 2 antibodyAnti-Pdz-Gef2 antibodyAnti-Ra-Gef-2 antibodyAnti-RAPGEF6 antibodyAnti-PDZGEF2 antibody |
Information sourced from Uniprot.org