| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Epac1 (824-923) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAPGEF3 |
| Gene ID: |
10411 |
| Uniprot ID: |
RPGF3_HUMAN |
| Immunogen Region: |
824-923 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 824-923 of human Epac1/RAPGEF3 (O95398). |
| Immunogen Sequence: |
FIHEGNHTLVENLINFEKMR MMARAARMLHHCRSHNPVPL SPLRSRVSHLHEDSQVARIS TCSEQSLSTRSPASTWAYVQ QLKVIDNQRELSRLSRELEP |
| Tissue Specificity | Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. |
| Function | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. |
| Protein Name | Rap Guanine Nucleotide Exchange Factor 3Exchange Factor Directly Activated By Camp 1Exchange Protein Directly Activated By Camp 1Epac 1Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CampCamp-Regulated Guanine Nucleotide Exchange Factor ICamp-Gefi |
| Database Links | Reactome: R-HSA-354192Reactome: R-HSA-381676Reactome: R-HSA-392517Reactome: R-HSA-422356 |
| Cellular Localisation | Endomembrane System |
| Alternative Antibody Names | Anti-Rap Guanine Nucleotide Exchange Factor 3 antibodyAnti-Exchange Factor Directly Activated By Camp 1 antibodyAnti-Exchange Protein Directly Activated By Camp 1 antibodyAnti-Epac 1 antibodyAnti-Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp antibodyAnti-Camp-Regulated Guanine Nucleotide Exchange Factor I antibodyAnti-Camp-Gefi antibodyAnti-RAPGEF3 antibodyAnti-CGEF1 antibodyAnti-EPAC antibodyAnti-EPAC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
