| Tissue Specificity | Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. |
| Function | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. |
| Protein Name | Rap Guanine Nucleotide Exchange Factor 3Exchange Factor Directly Activated By Camp 1Exchange Protein Directly Activated By Camp 1Epac 1Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CampCamp-Regulated Guanine Nucleotide Exchange Factor ICamp-Gefi |
| Database Links | Reactome: R-HSA-354192Reactome: R-HSA-381676Reactome: R-HSA-392517Reactome: R-HSA-422356 |
| Cellular Localisation | Endomembrane System |
| Alternative Antibody Names | Anti-Rap Guanine Nucleotide Exchange Factor 3 antibodyAnti-Exchange Factor Directly Activated By Camp 1 antibodyAnti-Exchange Protein Directly Activated By Camp 1 antibodyAnti-Epac 1 antibodyAnti-Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp antibodyAnti-Camp-Regulated Guanine Nucleotide Exchange Factor I antibodyAnti-Camp-Gefi antibodyAnti-RAPGEF3 antibodyAnti-CGEF1 antibodyAnti-EPAC antibodyAnti-EPAC1 antibody |
Information sourced from Uniprot.org
