| Tissue Specificity | Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver. |
| Post Translational Modifications | Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor. |
| Function | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. |
| Protein Name | Rap Guanine Nucleotide Exchange Factor 1Crk Sh3-Binding GnrpGuanine Nucleotide-Releasing Factor 2Protein C3g |
| Database Links | Reactome: R-HSA-170968Reactome: R-HSA-186763Reactome: R-HSA-8875555Reactome: R-HSA-9013423Reactome: R-HSA-9027284Reactome: R-HSA-912631 |
| Cellular Localisation | Early Endosome |
| Alternative Antibody Names | Anti-Rap Guanine Nucleotide Exchange Factor 1 antibodyAnti-Crk Sh3-Binding Gnrp antibodyAnti-Guanine Nucleotide-Releasing Factor 2 antibodyAnti-Protein C3g antibodyAnti-RAPGEF1 antibodyAnti-GRF2 antibody |
Information sourced from Uniprot.org
