• Western blot analysis of lysates from COS7 cells, using RAD51L1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunohistochemistry analysis of paraffin-embedded human pancreas tissue, using RAD51L1 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-RAD51B antibody (201-250 aa) (STJ95331)

SKU:
STJ95331

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DNA repair protein RAD51 homolog 2 (201-250 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RAD51B
Gene ID: 5890
Uniprot ID: RA51B_HUMAN
Immunogen Region: 201-250 aa
Specificity: Rad51B Polyclonal Antibody detects endogenous levels of Rad51B protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human RAD51L1 at the amino acid range 201-250
Post Translational Modifications Phosphorylated on tyrosine residues by BCR-ABL.
Function Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.
Protein Name Dna Repair Protein Rad51 Homolog 2
R51h2
Rad51 Homolog B
Rad51b
Rad51-Like Protein 1
Database Links Reactome: R-HSA-5685942
Reactome: R-HSA-5693554
Reactome: R-HSA-5693568
Reactome: R-HSA-5693579
Reactome: R-HSA-5693616
Reactome: R-HSA-9701192
Reactome: R-HSA-9704331
Reactome: R-HSA-9704646
Reactome: R-HSA-9709603
Reactome: R-HSA-983231
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Dna Repair Protein Rad51 Homolog 2 antibody
Anti-R51h2 antibody
Anti-Rad51 Homolog B antibody
Anti-Rad51b antibody
Anti-Rad51-Like Protein 1 antibody
Anti-RAD51B antibody
Anti-RAD51L1 antibody
Anti-REC2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance