| Function | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rad18Postreplication Repair Protein Rad18Hhr18Hrad18Ring Finger Protein 73Ring-Type E3 Ubiquitin Transferase Rad18 |
| Database Links | Reactome: R-HSA-110314Reactome: R-HSA-8866654 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeAssociates With ChromatinColocalizes With Slf1 In The Nucleus And To CentrosomesRelocalizes With Slf1 To Nuclear Foci In Response To Dna DamageAccumulates With The Slf1-Slf2 And Smc5-Smc6 Complexes At Replication-Coupled Dna Interstrand Repair And Dna Double-Strand Breaks (Dsbs) Sites On Chromatin In A Ubiquitin-Dependent Manner |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rad18 antibodyAnti-Postreplication Repair Protein Rad18 antibodyAnti-Hhr18 antibodyAnti-Hrad18 antibodyAnti-Ring Finger Protein 73 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rad18 antibodyAnti-RAD18 antibodyAnti-RNF73 antibody |
Information sourced from Uniprot.org
