Anti-RAB6A antibody (113-162 aa) (STJ95302)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RAB6A at the amino acid range 113-162
General Information
| Short Description | Rabbit polyclonal anti-Ras-related protein Rab-6A (113-162 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB6A |
| Gene ID | 5870 |
| Uniprot ID | RAB6A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RAB6A at the amino acid range 113-162 |
| Immunogen Region | 113-162 aa |
| Specificity | Rab 6A Polyclonal Antibody detects endogenous levels of Rab 6A protein. |
Additional Info
| Post Translational Modifications | Prenylated. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Recruits VPS13B to the Golgi membrane. Plays a role in neuron projection development (Probable). |
| Protein Name | Ras-Related Protein Rab-6aRab-6 |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-6798695Reactome: R-HSA-6811436Reactome: R-HSA-6811440Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorCytoplasmic VesicleSecretory VesicleAcrosome MembranePeripheral Membrane ProteinBicd2 Facilitates Its Targeting To Golgi Apparatus MembraneIsoform 1: Golgi Apparatus MembraneIsoform 2: Golgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-6a antibodyAnti-Rab-6 antibodyAnti-RAB6A antibodyAnti-RAB6 antibody |
Information sourced from Uniprot.org