| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB39A regulates autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex onto lysosomes.this process involves lysosomal RAB39A and autophagosomal RAB2A recruitment of HOPS subcomplexes VPS41-VPS16-VPS18-VPS33A and VPS39-VPS11, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion. Also negatively regulates lipopolysaccharide (LPS)-induced autophagosome formation in macrophages, possibly by implicating PI3K. Promotes the delivery of MHC-I molecules from the ER to phagosomes and the generation of peptide-loaded MHC-I complexes in phagosomes, thus enhancing antigen cross-presentation by dendritic cells. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. May be involved in multiple neurite formation. |
| Protein Name | Ras-Related Protein Rab-39aRab-39 |
| Database Links | Reactome: R-HSA-6811438Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmic VesiclePhagosome MembraneLysosome MembraneAutolysosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosisMajorly Localized On Lysosomes Under Basal ConditionsMajorly Localized On Autophagosomes/Autolysosomes Under Autophagy-Induced ConditionsColocalized With Vps39 And Vps41 On Lysosomes Or AutolysosomesColocalized With Stx17 On Autolysosomes In Autophagy-Induced ConditionsLocalized (Gtp-Bound) To Phagosomes In Dendritic CellsShuttles Vesicles From The Er-Golgi To The Phagosome |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-39a antibodyAnti-Rab-39 antibodyAnti-RAB39A antibodyAnti-RAB39 antibody |
Information sourced from Uniprot.org
