Anti-RAB38 antibody (80-129 aa) (STJ95298)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RAB38 at the amino acid range 80-129
General Information
| Short Description | Rabbit polyclonal anti-Ras-related protein Rab-38 (80-129 aa) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB38 |
| Gene ID | 23682 |
| Uniprot ID | RAB38_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RAB38 at the amino acid range 80-129 |
| Immunogen Region | 80-129 aa |
| Specificity | Rab 38 Polyclonal Antibody detects endogenous levels of Rab 38 protein. |
Additional Info
| Post Translational Modifications | Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB38 may be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes.the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. |
| Protein Name | Ras-Related Protein Rab-38Melanoma Antigen Ny-Mel-1 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideMelanosomeCytoplasmic VesiclePhagosomePhagosome MembraneMelanosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosisThe Bloc-3 ComplexA Heterodimer Of Hps1 And Hps4 Promotes Its Membrane Localization |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-38 antibodyAnti-Melanoma Antigen Ny-Mel-1 antibodyAnti-RAB38 antibody |
Information sourced from Uniprot.org