| Short Description : | Rabbit polyclonal RAB27B (1-218) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAB27B |
| Gene ID: | 5874 |
| Uniprot ID: | RB27B_HUMAN |
| Immunogen Region: | 1-218 |
| Immunogen Sequence: | MTDGDYDYLIKLLALGDSGV GKTTFLYRYTDNKFNPKFIT TVGIDFREKRVVYNAQGPNG SSGKAFKVHLQLWDTAGQER FRSLTTAFFRDAMGFLLMFD LTSQQSFLNVRNWMSQLQAN AYCENPDIVLIGNKADLPDQ REVNERQARELADKYGIPYF ETSAATGQNVEKAVETLLDL IMKRMEQCVEKTQIPDTVNG GNSGNLDGEKPPEKKCIC |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human RAB27B (NP_004154.2). |
| Tissue Specificity | Expressed primarily in testis. |
| Function | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1. May be involved in targeting uroplakins to urothelial apical membranes. |
| Protein Name | Ras-Related Protein Rab-27bC25kg |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | MembraneLipid-AnchorLate Endosome |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-27b antibodyAnti-C25kg antibodyAnti-RAB27B antibody |
Information sourced from Uniprot.org
