| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RAB18 (1-206) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAB18 |
| Gene ID: |
22931 |
| Uniprot ID: |
RAB18_HUMAN |
| Immunogen Region: |
1-206 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RAB18 (NP_067075.1). |
| Immunogen Sequence: |
MDEDVLTTLKILIIGESGVG KSSLLLRFTDDTFDPELAAT IGVDFKVKTISVDGNKAKLA IWDTAGQERFRTLTPSYYRG AQGVILVYDVTRRDTFVKLD NWLNELETYCTRNDIVNMLV GNKIDKENREVDRNEGLKFA RKHSMLFIEASAKTCDGVQC AFEELVEKIIQTPGLWESEN QNKGVKLSHREEGQGGGACG GYCSVL |
| Tissue Specificity | Ubiquitous. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration. |
| Protein Name | Ras-Related Protein Rab-18 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6811436Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Apical Cell MembraneLipid DropletEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-18 antibodyAnti-RAB18 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
