| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-QSOX1 (1-330) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
QSOX1 |
| Gene ID: |
5768 |
| Uniprot ID: |
QSOX1_HUMAN |
| Immunogen Region: |
1-330 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human QSOX1 (NP_001004128.1). |
| Immunogen Sequence: |
MRRCNSGSGPPPSLLLLLLW LLAVPGANAAPRSALYSPSD PLTLLQADTVRGAVLGSRSA WAVEFFASWCGHCIAFAPTW KALAEDVKAWRPALYLAALD CAEETNSAVCRDFNIPGFPT VRFFKAFTKNGSGAVFPVAG ADVQTLRERLIDALESHHDT WPPACPPLEPAKLEEIDGFF ARNNEEYLALIFEKGGSYLG REVALDLSQHKGVAVRRVLN TEANVVRKFGVTDFPSCYL |
| Tissue Specificity | Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney. |
| Post Translational Modifications | N-glycosylated. O-glycosylated on Thr and Ser residues. |
| Function | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration. |
| Protein Name | Sulfhydryl Oxidase 1HqsoxQuiescin Q6 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-6798695Reactome: R-HSA-8957275 |
| Cellular Localisation | Isoform 1: Golgi Apparatus MembraneSingle-Pass Membrane ProteinSecretedA Small Proportion Is SecretedProbably Via A Proteolytic Cleavage That Removes The Membrane AnchorIsoform 2: SecretedFound In The Extracellular Medium Of Quiescent Cells But Is Not Found In Proliferating Cells |
| Alternative Antibody Names | Anti-Sulfhydryl Oxidase 1 antibodyAnti-Hqsox antibodyAnti-Quiescin Q6 antibodyAnti-QSOX1 antibodyAnti-QSCN6 antibodyAnti-UNQ2520 antibodyAnti-PRO6013 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
