Anti-QSOX1 antibody (1-330) (STJ25251)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal QSOX1 (1-330) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | QSOX1 |
| Gene ID | 5768 |
| Uniprot ID | QSOX1_HUMAN |
| Immunogen Region | 1-330 |
| Immunogen Sequence | MRRCNSGSGPPPSLLLLLLW LLAVPGANAAPRSALYSPSD PLTLLQADTVRGAVLGSRSA WAVEFFASWCGHCIAFAPTW KALAEDVKAWRPALYLAALD CAEETNSAVCRDFNIPGFPT VRFFKAFTKNGSGAVFPVAG ADVQTLRERLIDALESHHDT WPPACPPLEPAKLEEIDGFF ARNNEEYLALIFEKGGSYLG REVALDLSQHKGVAVRRVLN TEANVVRKFGVTDFPSCYL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human QSOX1 (NP_001004128.1). |
Additional Info
| Tissue Specificity | Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney. |
| Post Translational Modifications | N-glycosylated. O-glycosylated on Thr and Ser residues. |
| Function | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration. |
| Protein Name | Sulfhydryl Oxidase 1HqsoxQuiescin Q6 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-6798695Reactome: R-HSA-8957275 |
| Cellular Localisation | Isoform 1: Golgi Apparatus MembraneSingle-Pass Membrane ProteinSecretedA Small Proportion Is SecretedProbably Via A Proteolytic Cleavage That Removes The Membrane AnchorIsoform 2: SecretedFound In The Extracellular Medium Of Quiescent Cells But Is Not Found In Proliferating Cells |
| Alternative Antibody Names | Anti-Sulfhydryl Oxidase 1 antibodyAnti-Hqsox antibodyAnti-Quiescin Q6 antibodyAnti-QSOX1 antibodyAnti-QSCN6 antibodyAnti-UNQ2520 antibodyAnti-PRO6013 antibody |
Information sourced from Uniprot.org