Anti-PYHIN1 antibody (338-388 aa) (STJ193945)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human IFIX at the amino acid range 338-388
General Information
| Short Description | Rabbit polyclonal anti-Pyrin and HIN domain-containing protein 1 (338-388 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PYHIN1 |
| Gene ID | 149628 |
| Uniprot ID | IFIX_HUMAN |
| Immunogen | Synthesized peptide derived from the human IFIX at the amino acid range 338-388 |
| Immunogen Region | 338-388 aa |
| Specificity | This antibody detects endogenous levels of IFIX at Human/Mouse |
Additional Info
| Function | Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. |
| Protein Name | Pyrin And Hin Domain-Containing Protein 1Interferon-Inducible Protein X |
| Database Links | |
| Cellular Localisation | Isoform 1: NucleusNucleoplasmIsoform 3: NucleusIsoform 5: NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Pyrin And Hin Domain-Containing Protein 1 antibodyAnti-Interferon-Inducible Protein X antibodyAnti-PYHIN1 antibodyAnti-IFIX antibody |
Information sourced from Uniprot.org