| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PYCR1 |
| Gene ID: | 5831 |
| Uniprot ID: | P5CR1_HUMAN |
| Immunogen Region: | 1-319 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-319 of human PYCR1 (NP_008838.2). |
| Immunogen Sequence: | MSVGFIGAGQLAFALAKGFT AAGVLAAHKIMASSPDMDLA TVSALRKMGVKLTPHNKETV QHSDVLFLAVKPHIIPFILD EIGADIEDRHIVVSCAAGVT ISSIEKKLSAFRPAPRVIRC MTNTPVVVREGATVYATGTH AQVEDGRLMEQLLSSVGFCT EVEEDLIDAVTGLSGSGPAY AFTALDALADGGVKMGLPRR LAVRLGAQALLGAAKMLLHS EQHPGQLKDNVSSPGGATI |
| Function | Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in the cellular response to oxidative stress. |
| Protein Name | Pyrroline-5-Carboxylate Reductase 1 - MitochondrialP5c Reductase 1P5cr 1 |
| Database Links | Reactome: R-HSA-8964539 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Pyrroline-5-Carboxylate Reductase 1 - Mitochondrial antibodyAnti-P5c Reductase 1 antibodyAnti-P5cr 1 antibodyAnti-PYCR1 antibody |
Information sourced from Uniprot.org
