| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PUS7 (352-661) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PUS7 |
| Gene ID: |
54517 |
| Uniprot ID: |
PUS7_HUMAN |
| Immunogen Region: |
352-661 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 352-661 of human PUS7 (NP_061915.2). |
| Immunogen Sequence: |
ITGTDDQVQQAMNSLKEIGF INYYGMQRFGTTAVPTYQVG RAILQNSWTEVMDLILKPRS GAEKGYLVKCREEWAKTKDP TAALRKLPVKRCVEGQLLRG LSKYGMKNIVSAFGIIPRNN RLMYIHSYQSYVWNNMVSKR IEDYGLKPVPGDLVLKGATA TYIEEDDVNNYSIHDVVMPL PGFDVIYPKHKIQEAYREML TADNLDIDNMRHKIRDYSLS GAYRKIIIRPQNVSWEVVA |
| Function | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types. |
| Protein Name | Pseudouridylate Synthase 7 Homolog |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pseudouridylate Synthase 7 Homolog antibodyAnti-PUS7 antibodyAnti-KIAA1897 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
