Anti-PTPRU antibody (1-100) (STJ110773)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PTPRU (1-100) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTPRU |
| Gene ID | 10076 |
| Uniprot ID | PTPRU_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MARAQALVLALTFQLCAPET ETPAAGCTFEEASDPAVPCE YSQAQYDDFQWEQVRIHPGT RAPADLPHGSYLMVNTSQHA PGQRAHVIFQSLSENDTHCV |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTPRU (NP_005695.3). |
Additional Info
| Tissue Specificity | High levels in brain, pancreas, and skeletal muscle.less in colon, kidney, liver, stomach, and uterus.not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells. |
| Post Translational Modifications | The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain. In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed. N-glycosylated. Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated. |
| Function | Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase UR-Ptp-UPancreatic Carcinoma Phosphatase 2Pcp-2Protein-Tyrosine Phosphatase JPtp-JHptp-JProtein-Tyrosine Phosphatase PiPtp PiProtein-Tyrosine Phosphatase Receptor OmicronPtp-RoReceptor-Type Protein-Tyrosine Phosphatase PsiR-Ptp-Psi |
| Database Links | Reactome: R-HSA-1433557 |
| Cellular Localisation | Cell JunctionCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase U antibodyAnti-R-Ptp-U antibodyAnti-Pancreatic Carcinoma Phosphatase 2 antibodyAnti-Pcp-2 antibodyAnti-Protein-Tyrosine Phosphatase J antibodyAnti-Ptp-J antibodyAnti-Hptp-J antibodyAnti-Protein-Tyrosine Phosphatase Pi antibodyAnti-Ptp Pi antibodyAnti-Protein-Tyrosine Phosphatase Receptor Omicron antibodyAnti-Ptp-Ro antibodyAnti-Receptor-Type Protein-Tyrosine Phosphatase Psi antibodyAnti-R-Ptp-Psi antibodyAnti-PTPRU antibodyAnti-FMI antibodyAnti-PCP2 antibodyAnti-PTPRO antibody |
Information sourced from Uniprot.org