| Short Description : | Rabbit polyclonal PTPRD (475-574) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPRD |
| Gene ID: | 5789 |
| Uniprot ID: | PTPRD_HUMAN |
| Immunogen Region: | 475-574 |
| Immunogen Sequence: | QITTIGNLVPQKTYSVKVLA FTSIGDGPLSSDIQVITQTG VPGQPLNFKAEPESETSILL SWTPPRSDTIANYELVYKDG EHGEEQRITIEPGTSYRLQG |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 475-574 of human PTPRD (NP_002830.1). |
| Post Translational Modifications | A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization. |
| Function | Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase DeltaProtein-Tyrosine Phosphatase DeltaR-Ptp-Delta |
| Database Links | Reactome: R-HSA-388844Reactome: R-HSA-8849932 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase Delta antibodyAnti-Protein-Tyrosine Phosphatase Delta antibodyAnti-R-Ptp-Delta antibodyAnti-PTPRD antibody |
Information sourced from Uniprot.org
