• Western blot analysis of lysates from U-251 MG cells using PTPRB Rabbit polyclonal antibody (STJ11105723) at 1:800 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25  Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-PTPRB antibody (1173-1260) (STJ11105723)

SKU:
STJ11105723

£112.50 - £522.50
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Receptor-Type Tyrosine-Protein Phosphatase Beta (1173-1260) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTPRB
Gene ID: 5787
Uniprot ID: PTPRB_HUMAN
Immunogen Region: 1173-1260
Immunogen: Recombinant Protein corresponding to a sequence within amino acids 1173-1260 of human PTPRB (NP_002828.3).
Immunogen Sequence: PASVSHLRGSNRNTTDSLWF NWSPASGDFDFYELILYNPN GTKKENWKDKDLTEWRFQGL VPGRKYVLWVVTHSGDLSNK VTAESRTA
Function Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase Beta
Protein-Tyrosine Phosphatase Beta
R-Ptp-Beta
Vascular Endothelial Protein Tyrosine Phosphatase
Ve-Ptp
Database Links Reactome: R-HSA-6798695
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Receptor-Type Tyrosine-Protein Phosphatase Beta antibody
Anti-Protein-Tyrosine Phosphatase Beta antibody
Anti-R-Ptp-Beta antibody
Anti-Vascular Endothelial Protein Tyrosine Phosphatase antibody
Anti-Ve-Ptp antibody
Anti-PTPRB antibody
Anti-PTPB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance