Anti-PTK7/CCK-4 nanobody [SAA2288] (STJN000678)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
General Information
| Short Description | Alpaca monoclonal nanobody anti-PTK7/CCK-4 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2288 |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Purified by Nickel column. |
| Dilution Range | ELISA: 1:2000-1:20000 |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact with the lab for this information. |
Target Information
| Gene Symbol | PTK7 |
| Gene ID | 5754 |
| Uniprot ID | PTK7_HUMAN |
Additional Info
| Post Translational Modifications | MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway. |
| Function | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. |
| Protein Name | Inactive Tyrosine-Protein Kinase 7Colon Carcinoma Kinase 4Cck-4Protein-Tyrosine Kinase 7Pseudo Tyrosine Kinase Receptor 7Tyrosine-Protein Kinase-Like 7 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell JunctionColocalizes With Mmp14 At Cell JunctionsAlso Localizes At The Leading Edge Of Migrating Cells |
| Alternative Nanobody Names | Anti-Inactive Tyrosine-Protein Kinase 7 nanobodyAnti-Colon Carcinoma Kinase 4 nanobodyAnti-Cck-4 nanobodyAnti-Protein-Tyrosine Kinase 7 nanobodyAnti-Pseudo Tyrosine Kinase Receptor 7 nanobodyAnti-Tyrosine-Protein Kinase-Like 7 nanobodyAnti-PTK7 nanobodyAnti-CCK4 nanobody |
Information sourced from Uniprot.org