| Tissue Specificity | Expressed in most tissues. Most abundant in kidney, bone and liver. |
| Post Translational Modifications | N-glycosylated. |
| Function | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH.as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH. |
| Protein Name | Parathyroid Hormone/Parathyroid Hormone-Related Peptide ReceptorPth/Pthrp Type I ReceptorPth/Pthr ReceptorParathyroid Hormone 1 ReceptorPth1 Receptor |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor antibodyAnti-Pth/Pthrp Type I Receptor antibodyAnti-Pth/Pthr Receptor antibodyAnti-Parathyroid Hormone 1 Receptor antibodyAnti-Pth1 Receptor antibodyAnti-PTH1R antibodyAnti-PTHR antibodyAnti-PTHR1 antibody |
Information sourced from Uniprot.org
