| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTH1R |
| Gene ID: | 5745 |
| Uniprot ID: | PTH1R_HUMAN |
| Immunogen Region: | 27-593 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-188 of human PTH1R (NP_000307.1). |
| Immunogen Sequence: | DADDVMTKEEQIFLLHRAQA QCEKRLKEVLQRPASIMESD KGWTSASTSGKPRKDKASGK LYPESEEDKEAPTGSRYRGR PCLPEWDHILCWPLGAPGEV VAVPCPDYIYDFNHKGHAYR RCDRNGSWELVPGHNRTWAN YSECVKFLTNETREREVFDR LG |
| Tissue Specificity | Expressed in most tissues. Most abundant in kidney, bone and liver. |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. |
| Protein Name | Parathyroid Hormone/Parathyroid Hormone-Related Peptide ReceptorPth/Pthrp Type I ReceptorPth/Pthr ReceptorParathyroid Hormone 1 ReceptorPth1 Receptor |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor antibodyAnti-Pth/Pthrp Type I Receptor antibodyAnti-Pth/Pthr Receptor antibodyAnti-Parathyroid Hormone 1 Receptor antibodyAnti-Pth1 Receptor antibodyAnti-PTH1R antibodyAnti-PTHR antibodyAnti-PTHR1 antibody |
Information sourced from Uniprot.org