Anti-PTGR1 antibody (75-124 aa) (STJ93962)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PTGR1 at the amino acid range 75-124
General Information
| Short Description | Rabbit polyclonal anti-Prostaglandin reductase 1H-dependent alkenal/one oxidoreductase (75-124 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTGR1 |
| Gene ID | 22949 |
| Uniprot ID | PTGR1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PTGR1 at the amino acid range 75-124 |
| Immunogen Region | 75-124 aa |
| Specificity | LTB4DH Polyclonal Antibody detects endogenous levels of LTB4DH protein. |
Additional Info
| Function | NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one. May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles. |
| Protein Name | Prostaglandin Reductase 1Prg-115-Oxoprostaglandin 13-ReductaseDithiolethione-Inducible Gene 1 ProteinD3t-Inducible Gene 1 ProteinDig-1Leukotriene B4 12-HydroxydehydrogenaseNad(Ph-Dependent Alkenal/One Oxidoreductase |
| Database Links | Reactome: R-HSA-2142691Reactome: R-HSA-2142700 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Prostaglandin Reductase 1 antibodyAnti-Prg-1 antibodyAnti-15-Oxoprostaglandin 13-Reductase antibodyAnti-Dithiolethione-Inducible Gene 1 Protein antibodyAnti-D3t-Inducible Gene 1 Protein antibodyAnti-Dig-1 antibodyAnti-Leukotriene B4 12-Hydroxydehydrogenase antibodyAnti-Nad(Ph-Dependent Alkenal/One Oxidoreductase antibodyAnti-PTGR1 antibodyAnti-LTB4DH antibody |
Information sourced from Uniprot.org