| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTGES2 (88-377) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTGES2 |
| Gene ID: |
80142 |
| Uniprot ID: |
PGES2_HUMAN |
| Immunogen Region: |
88-377 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 88-377 of human PTGES2 (NP_079348.1). |
| Immunogen Sequence: |
ERSAAQLSLSSRLQLTLYQY KTCPFCSKVRAFLDFHALPY QVVEVNPVRRAEIKFSSYRK VPILVAQEGESSQQLNDSSV IISALKTYLVSGQPLEEIIT YYPAMKAVNEQGKEVTEFGN KYWLMLNEKEAQQVYGGKEA RTEEMKWRQWADDWLVHLIS PNVYRTPTEALASFDYIVRE GKFGAVEGAVAKYMGAAAMY LISKRLKSRHRLQDNVREDL YEAADKWVAAVGKDRPFMG |
| Tissue Specificity | Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum.occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer. |
| Post Translational Modifications | Synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. |
| Function | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA). |
| Protein Name | Prostaglandin E Synthase 2Membrane-Associated Prostaglandin E Synthase-2Mpge Synthase-2Microsomal Prostaglandin E Synthase 2Mpges-2Prostaglandin-H(2 E-Isomerase Cleaved Into - Prostaglandin E Synthase 2 Truncated Form |
| Database Links | Reactome: R-HSA-2162123Reactome: R-HSA-6798695 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Membrane ProteinProstaglandin E Synthase 2 Truncated Form: CytoplasmPerinuclear RegionSynthesized As A Golgi Membrane-Bound ProteinWhich Is Further Cleaved Into The Predominant Soluble Truncated FormThe Truncated Form Is Cytoplasmic And Is Enriched In The Perinuclear Region |
| Alternative Antibody Names | Anti-Prostaglandin E Synthase 2 antibodyAnti-Membrane-Associated Prostaglandin E Synthase-2 antibodyAnti-Mpge Synthase-2 antibodyAnti-Microsomal Prostaglandin E Synthase 2 antibodyAnti-Mpges-2 antibodyAnti-Prostaglandin-H(2 E-Isomerase Cleaved Into - Prostaglandin E Synthase 2 Truncated Form antibodyAnti-PTGES2 antibodyAnti-C9orf15 antibodyAnti-PGES2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
