Anti-PTGDR antibody (263-312 aa) (STJ94989)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PTGDR at the amino acid range 263-312
General Information
| Short Description | Rabbit polyclonal anti-Prostaglandin D2 receptor (263-312 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTGDR |
| Gene ID | 5729 |
| Uniprot ID | PD2R_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PTGDR at the amino acid range 263-312 |
| Immunogen Region | 263-312 aa |
| Specificity | PD2R Polyclonal Antibody detects endogenous levels of PD2R protein. |
Additional Info
| Function | Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR. |
| Protein Name | Prostaglandin D2 ReceptorPgd ReceptorPgd2 ReceptorProstanoid Dp Receptor |
| Database Links | Reactome: R-HSA-391908Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Prostaglandin D2 Receptor antibodyAnti-Pgd Receptor antibodyAnti-Pgd2 Receptor antibodyAnti-Prostanoid Dp Receptor antibodyAnti-PTGDR antibody |
Information sourced from Uniprot.org