Anti-PSPC1 antibody (10-90 aa) (STJ191131)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 10-90
General Information
| Short Description | Rabbit polyclonal anti-Paraspeckle component 1 (10-90 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PSPC1 |
| Gene ID | 55269 |
| Uniprot ID | PSPC1_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 10-90 |
| Immunogen Region | 10-90 aa |
| Specificity | PSPC1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | RNA-binding protein required for the formation of nuclear paraspeckles. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Paraspeckle Component 1Paraspeckle Protein 1 |
| Database Links | |
| Cellular Localisation | Nucleus SpeckleNucleusNucleolusNucleus MatrixCytoplasmIn Punctate Subnuclear Structures Often Located Adjacent To Splicing SpecklesCalled ParaspecklesColocalizes With Nono And Sfpq In Paraspeckles And Perinucleolar Caps In An Rna-Dependent MannerMay Cycle Between Paraspeckles And NucleolusIn TelophaseWhen Daughter Nuclei FormLocalizes To Perinucleolar Caps |
| Alternative Antibody Names | Anti-Paraspeckle Component 1 antibodyAnti-Paraspeckle Protein 1 antibodyAnti-PSPC1 antibodyAnti-PSP1 antibody |
Information sourced from Uniprot.org