| Tissue Specificity | Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. |
| Function | RNA-binding protein required for the formation of nuclear paraspeckles. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Paraspeckle Component 1Paraspeckle Protein 1 |
| Cellular Localisation | Nucleus SpeckleNucleusNucleolusNucleus MatrixCytoplasmIn Punctate Subnuclear Structures Often Located Adjacent To Splicing SpecklesCalled ParaspecklesColocalizes With Nono And Sfpq In Paraspeckles And Perinucleolar Caps In An Rna-Dependent MannerMay Cycle Between Paraspeckles And NucleolusIn TelophaseWhen Daughter Nuclei FormLocalizes To Perinucleolar Caps |
| Alternative Antibody Names | Anti-Paraspeckle Component 1 antibodyAnti-Paraspeckle Protein 1 antibodyAnti-PSPC1 antibodyAnti-PSP1 antibody |
Information sourced from Uniprot.org
