| Tissue Specificity | In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines. |
| Post Translational Modifications | Degraded by the proteasome upon completion of 20S proteasome maturation. |
| Function | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. |
| Protein Name | Proteasome Assembly Chaperone 1Pac-1Chromosome 21 Leucine-Rich ProteinC21-LrpDown Syndrome Critical Region Protein 2Proteasome Chaperone Homolog 1Pba1 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Proteasome Assembly Chaperone 1 antibodyAnti-Pac-1 antibodyAnti-Chromosome 21 Leucine-Rich Protein antibodyAnti-C21-Lrp antibodyAnti-Down Syndrome Critical Region Protein 2 antibodyAnti-Proteasome Chaperone Homolog 1 antibodyAnti-Pba1 antibodyAnti-PSMG1 antibodyAnti-C21LRP antibodyAnti-DSCR2 antibodyAnti-PAC1 antibody |
Information sourced from Uniprot.org
