| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PSMC3 (1-180) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PSMC3 |
| Gene ID: | 5702 |
| Uniprot ID: | PRS6A_HUMAN |
| Immunogen Region: | 1-180 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human PSMC3 (NP_002799.3). |
| Immunogen Sequence: | MEEGGRDKAPVQPQQSPAAA PGGTDEKPSGKERRDAGDKD KEQELSEEDKQLQDELEMLV ERLGEKDTSLYRPALEELRR QIRSSTTSMTSVPKPLKFLR PHYGKLKEIYENMAPGENKR FAADIISVLAMTMSGERECL KYRLVGSQEELASWGHEYVR HLAGEVAKEWQELDDAEKVQ |
| Post Translational Modifications | Sumoylated by UBE2I in response to MEKK1-mediated stimuli. |
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. |
| Protein Name | 26s Proteasome Regulatory Subunit 6a26s Proteasome Aaa-Atpase Subunit Rpt5Proteasome 26s Subunit Atpase 3Proteasome Subunit P50Tat-Binding Protein 1Tbp-1 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1234176Reactome: R-HSA-1236974Reactome: R-HSA-1236978Reactome: R-HSA-174084Reactome: R-HSA-174113Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-180534Reactome: R-HSA-180585Reactome: R-HSA-187577Reactome: R-HSA-195253Reactome: R-HSA-202424Reactome: R-HSA-211733Reactome: R-HSA-2467813Reactome: R-HSA-2871837Reactome: R-HSA-349425Reactome: R-HSA-350562Reactome: R-HSA-382556Reactome: R-HSA-450408Reactome: R-HSA-4608870Reactome: R-HSA-4641257Reactome: R-HSA-4641258Reactome: R-HSA-5358346Reactome: R-HSA-5362768Reactome: R-HSA-5607761Reactome: R-HSA-5607764Reactome: R-HSA-5610780Reactome: R-HSA-5610783Reactome: R-HSA-5610785Reactome: R-HSA-5632684Reactome: R-HSA-5658442Reactome: R-HSA-5668541Reactome: R-HSA-5676590Reactome: R-HSA-5678895Reactome: R-HSA-5687128Reactome: R-HSA-5689603Reactome: R-HSA-5689880Reactome: R-HSA-6798695Reactome: R-HSA-68867Reactome: R-HSA-68949Reactome: R-HSA-69017Reactome: R-HSA-69481Reactome: R-HSA-69601Reactome: R-HSA-75815Reactome: R-HSA-8852276Reactome: R-HSA-8854050Reactome: R-HSA-8939236Reactome: R-HSA-8939902Reactome: R-HSA-8941858Reactome: R-HSA-8948751Reactome: R-HSA-8951664Reactome: R-HSA-9010553Reactome: R-HSA-9020702Reactome: R-HSA-9604323Reactome: R-HSA-9755511Reactome: R-HSA-9762114Reactome: R-HSA-9824272Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusColocalizes With Trim5 In The Cytoplasmic Bodies |
| Alternative Antibody Names | Anti-26s Proteasome Regulatory Subunit 6a antibodyAnti-26s Proteasome Aaa-Atpase Subunit Rpt5 antibodyAnti-Proteasome 26s Subunit Atpase 3 antibodyAnti-Proteasome Subunit P50 antibodyAnti-Tat-Binding Protein 1 antibodyAnti-Tbp-1 antibodyAnti-PSMC3 antibodyAnti-TBP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
