| Tissue Specificity | Isoform 1: Widely expressed in embryonic and adult tissues, with highest levels in skeletal muscle. Isoform 1 is either expressed at similar or higher levels compared to isoform 2 in all embryonic tissues but skeletal muscle and heart. In adult tissues, expressed at lower levels compared to isoform 2. Isoform 2: Widely expressed in embryonic and adult tissues, with highest levels in skeletal muscle. Isoform 2 is either expressed at similar or lower levels compared to isoform 1 in all embryonic tissues but skeletal muscle and heart, where it is expressed at higher levels. In adult tissues, expressed at higher levels compared to isoform 1. |
| Function | Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process. Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. May play a role in homeostasis and regeneration of bone, white adipose tissue and derm. Isoform 1: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. Isoform 2: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. |
| Protein Name | Paired Mesoderm Homeobox Protein 1Homeobox Protein Phox1Paired-Related Homeobox Protein 1Prx-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Mesoderm Homeobox Protein 1 antibodyAnti-Homeobox Protein Phox1 antibodyAnti-Paired-Related Homeobox Protein 1 antibodyAnti-Prx-1 antibodyAnti-PRRX1 antibodyAnti-PMX1 antibody |
Information sourced from Uniprot.org
