| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRPH |
| Gene ID: | 5630 |
| Uniprot ID: | PERI_HUMAN |
| Immunogen Region: | 1-260 |
| Immunogen Sequence: | MSHHPSGLRAGFSSTSYRRT FGPPPSLSPGAFSYSSSSRF SSSRLLGSASPSSSVRLGSF RSPRAGAGALLRLPSERLDF SMAEALNQEFLATRSNEKQE LQELNDRFANFIEKVRFLEQ QNAALRGELSQARGQEPARA DQLCQQELRELRRELELLGR ERDRVQVERDGLAEDLAALK QRLEEETRKREDAEHNLVLF RKDVDDATLSRLELERKIES LMDEIEFLKKLHEEELRDL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PRPH (NP_006253.2). |
| Tissue Specificity | Expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells. |
| Post Translational Modifications | Phosphorylated.phosphorylation increases after nerve injury in regenerating neurons. |
| Function | Class-III neuronal intermediate filament protein. May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network. Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury. Inhibits neurite extension in type II spiral ganglion neurons in the cochlea. |
| Protein Name | PeripherinNeurofilament 4 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonPerikaryon |
| Alternative Antibody Names | Anti-Peripherin antibodyAnti-Neurofilament 4 antibodyAnti-PRPH antibodyAnti-NEF4 antibodyAnti-PRPH1 antibody |
Information sourced from Uniprot.org
