![Anti-protein-tyrosine kinase/p561ck antibody [LCK-01] (STJ16100175)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148893/346536/STJ16100175_1__84948.1681998589.jpg?c=1 "Anti-protein-tyrosine kinase/p561ck antibody [LCK-01] (STJ16100175)")
![Anti-protein-tyrosine kinase/p561ck antibody [LCK-01] (STJ16100175)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/148893/346536/STJ16100175_1__84948.1681998589.jpg?c=1 "Anti-protein-tyrosine kinase/p561ck antibody [LCK-01] (STJ16100175)")
Anti-protein-tyrosine kinase/p561ck antibody [LCK-01] (STJ16100175)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPeptide corresponding to amino acids 22-36 in the sequence of human Lck.
General Information
| Short Description | Mouse monoclonal anti-protein-tyrosine kinase/p561ck for use in FC, IP, WB and ICC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IP/WB/ICC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | LCK-01 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Formulation | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | Peptide corresponding to amino acids 22-36 in the sequence of human Lck. |
Additional Info
| Background | Lck is a Src-family tyrosine kinase, which is essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, Lck phosphorylates the ITAM motives in its zeta subunits, establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by Lck and thereby activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. Whereas the majority of Lck is localized to the plasma membrane, there is also a significant fraction associated with the Golgi apparatus, which may contribute to Raf activation under conditions of weak stimulation through the TCR. Lck is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors. |
Information sourced from Uniprot.org