| Short Description : | Rabbit polyclonal PROCR (19-209) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PROCR |
| Gene ID: | 10544 |
| Uniprot ID: | EPCR_HUMAN |
| Immunogen Region: | 19-209 |
| Immunogen Sequence: | QDASDGLQRLHMLQISYFRD PYHVWYQGNASLGGHLTHVL EGPDTNTTIIQLQPLQEPES WARTQSGLQSYLLQFHGLVR LVHQERTLAFPLTIRCFLGC ELPPEGSRAHVFFEVAVNGS SFVSFRPERALWQADTQVTS GVVTFTLQQLNAYNRTRYEL REFLEDTCVQYVQKHISAEN TKGSQTSRSYT |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-209 of human PROCR (NP_006395.2). |
| Tissue Specificity | Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. |
| Post Translational Modifications | N-glycosylated. A soluble form exists.probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form. |
| Function | Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex.plays a role in the protein C pathway controlling blood coagulation. |
| Protein Name | Endothelial Protein C ReceptorActivated Protein C ReceptorApc ReceptorEndothelial Cell Protein C ReceptorCd Antigen Cd201 |
| Database Links | Reactome: R-HSA-140875Reactome: R-HSA-202733 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Endothelial Protein C Receptor antibodyAnti-Activated Protein C Receptor antibodyAnti-Apc Receptor antibodyAnti-Endothelial Cell Protein C Receptor antibodyAnti-Cd Antigen Cd201 antibodyAnti-PROCR antibodyAnti-EPCR antibody |
Information sourced from Uniprot.org
