| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PREX1 |
| Gene ID: | 57580 |
| Uniprot ID: | PREX1_HUMAN |
| Immunogen Region: | 1000-1300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1300 of human PREX1 (NP_065871.2). |
| Immunogen Sequence: | PSLIGLDPEQGHLNPMSYTQ HCITTMAAPSWKCLPAAEGD PQGQGLHDGSFGPASGTLGQ EDRGLSFLLKQEDREIQDAY LQLFTKLDVALKEMKQYVTQ INRLLSTITEPTSGGSCDAS LAEEASSLPLVSEESEMDRS DHGGIKKVCFKVAEEDQEDS GHDTMSYRDSYSECNSNRDS VLSYTSVRSNSSYLGSDEMG SGDELPCDMRIPSDKQDKLH GCLEHLFNQVDSINALLKG |
| Tissue Specificity | Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. |
| Function | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Protein Name | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 ProteinP-Rex1Ptdins(3 -4 -5-Dependent Rac Exchanger 1 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013406Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCytosolCell MembraneMainly CytosolicSome Amount Is Apparently Associated To The Plasma Membrane |
| Alternative Antibody Names | Anti-Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein antibodyAnti-P-Rex1 antibodyAnti-Ptdins(3 -4 -5-Dependent Rac Exchanger 1 antibodyAnti-PREX1 antibodyAnti-KIAA1415 antibody |
Information sourced from Uniprot.org
