| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRDM12 |
| Gene ID: | 59335 |
| Uniprot ID: | PRD12_HUMAN |
| Immunogen Region: | 100-330 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-330 of human PRDM12 (NP_067632.2). |
| Immunogen Sequence: | LGIFSKTWIKAGTEMGPFTG RVIAPEHVDICKNNNLMWEV FNEDGTVRYFIDASQEDHRS WMTYIKCARNEQEQNLEVVQ IGTSIFYKAIEMIPPDQELL VWYGNSHNTFLGIPGVPGLE EDQKKNKHEDFHPADSAAGP AGRMRCVICHRGFNSRSNLR SHMRIHTLDKPFVCRFCNRR FSQSSTLRNHVRLHTGERPY KCQVCQSAYSQLAGLRAHQK SARHRPPSTAL |
| Tissue Specificity | Not found in adult tissues except in dorsal root ganglia. |
| Function | Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli. |
| Protein Name | Pr Domain Zinc Finger Protein 12Pr Domain-Containing Protein 12 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pr Domain Zinc Finger Protein 12 antibodyAnti-Pr Domain-Containing Protein 12 antibodyAnti-PRDM12 antibodyAnti-PFM9 antibody |
Information sourced from Uniprot.org
