| Tissue Specificity | Expressed in testis. Detected in samples of kidney, brain and skin. |
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. |
| Protein Name | Melanoma Antigen Preferentially Expressed In TumorsOpa-Interacting Protein 4Oip-4Preferentially Expressed Antigen Of Melanoma |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCytoplasmGolgi ApparatusCell MembraneAssociates With ChromatinSpecifically Enriched At Transcriptionally Active Promoters That Are Also Bound By Nuclear Transcription Factor Y (Composed Of NfyaNfyb And Nfyc) And At EnhancersRecruited To The Golgi Apparatus In Response To Interferon Gamma (Ifng) Treatment |
| Alternative Antibody Names | Anti-Melanoma Antigen Preferentially Expressed In Tumors antibodyAnti-Opa-Interacting Protein 4 antibodyAnti-Oip-4 antibodyAnti-Preferentially Expressed Antigen Of Melanoma antibodyAnti-PRAME antibodyAnti-MAPE antibodyAnti-OIP4 antibody |
Information sourced from Uniprot.org
