| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPP2R4 (1-323) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTPA |
| Gene ID: |
5524 |
| Uniprot ID: |
PTPA_HUMAN |
| Immunogen Region: |
1-323 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human Ser/thr-PP2A activator (PTPA) (NP_821067.1). |
| Immunogen Sequence: |
MAEGERQPPPDSSEEAPPAT QNFIIPKKEIHTVPDMGKWK RSQAYADYIGFILTLNEGVK GKKLTFEYRVSEAIEKLVAL LNTLDRWIDETPPVDQPSRF GNKAYRTWYAKLDEEAENLV ATVVPTHLAAAVPEVAVYLK ESVGNSTRIDYGTGHEAAFA AFLCCLCKIGVLRVDDQIAI VFKVFNRYLEVMRKLQKTYR MEPAGSQGVWGLDDFQFLPF IWGSSQLIDHPYLEPRHFV |
| Tissue Specificity | Widely expressed. |
| Function | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis.the function appears to be independent from PP2A. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a ActivatorPp2a - Subunit B' - Pr53 IsoformPhosphotyrosyl Phosphatase ActivatorPtpaSerine/Threonine-Protein Phosphatase 2a Regulatory Subunit 4Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit B' |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a Activator antibodyAnti-Pp2a - Subunit B' - Pr53 Isoform antibodyAnti-Phosphotyrosyl Phosphatase Activator antibodyAnti-Ptpa antibodyAnti-Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit 4 antibodyAnti-Serine/Threonine-Protein Phosphatase 2a Regulatory Subunit B' antibodyAnti-PTPA antibodyAnti-PPP2R4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and ERCC1 knockout (KO) HeLa cells, using [KO Validated] ERCC1 Rabbit polyclonal antibody (STJ11100039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89111/357565/STJ11100039_1__56308.1713121691.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ERCC1 knockout (KO) HeLa cells, using [KO Validated] ERCC1 Rabbit polyclonal antibody (STJ11100039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.")
