| Function | Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the dephosphorylation of EEF1A1. |
| Protein Name | Protein Phosphatase 1 Regulatory Inhibitor Subunit 16bAnkyrin Repeat Domain-Containing Protein 4Caax Box Protein TimapTgf-Beta-Inhibited Membrane-Associated ProteinHtimap |
| Cellular Localisation | Cell MembraneLipid-AnchorNucleusCell ProjectionColocalizes With Rpsa/Lamr1 In The Cell MembraneLocalizes To The Perinuclear RegionColocalizes With Pten At The Tip Of Ec Projections |
| Alternative Antibody Names | Anti-Protein Phosphatase 1 Regulatory Inhibitor Subunit 16b antibodyAnti-Ankyrin Repeat Domain-Containing Protein 4 antibodyAnti-Caax Box Protein Timap antibodyAnti-Tgf-Beta-Inhibited Membrane-Associated Protein antibodyAnti-Htimap antibodyAnti-PPP1R16B antibodyAnti-ANKRD4 antibodyAnti-KIAA0823 antibody |
Information sourced from Uniprot.org
