Anti-PPP1R16B antibody (364-413 aa) (STJ96022)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PPP1R16B at the amino acid range 364-413
General Information
| Short Description | Rabbit polyclonal anti-Protein phosphatase 1 regulatory inhibitor subunit 16B (364-413 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPP1R16B |
| Gene ID | 26051 |
| Uniprot ID | PP16B_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PPP1R16B at the amino acid range 364-413 |
| Immunogen Region | 364-413 aa |
| Specificity | TIMAP Polyclonal Antibody detects endogenous levels of TIMAP protein. |
Additional Info
| Function | Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the dephosphorylation of EEF1A1. |
| Protein Name | Protein Phosphatase 1 Regulatory Inhibitor Subunit 16bAnkyrin Repeat Domain-Containing Protein 4Caax Box Protein TimapTgf-Beta-Inhibited Membrane-Associated ProteinHtimap |
| Database Links | |
| Cellular Localisation | Cell MembraneLipid-AnchorNucleusCell ProjectionColocalizes With Rpsa/Lamr1 In The Cell MembraneLocalizes To The Perinuclear RegionColocalizes With Pten At The Tip Of Ec Projections |
| Alternative Antibody Names | Anti-Protein Phosphatase 1 Regulatory Inhibitor Subunit 16b antibodyAnti-Ankyrin Repeat Domain-Containing Protein 4 antibodyAnti-Caax Box Protein Timap antibodyAnti-Tgf-Beta-Inhibited Membrane-Associated Protein antibodyAnti-Htimap antibodyAnti-PPP1R16B antibodyAnti-ANKRD4 antibodyAnti-KIAA0823 antibody |
Information sourced from Uniprot.org