| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein phosphatase 1 regulatory inhibitor subunit 16B (364-413 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP1R16B |
| Gene ID: | 26051 |
| Uniprot ID: | PP16B_HUMAN |
| Immunogen Region: | 364-413 aa |
| Specificity: | TIMAP Polyclonal Antibody detects endogenous levels of TIMAP protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PPP1R16B at the amino acid range 364-413 |
| Function | Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the dephosphorylation of EEF1A1. |
| Protein Name | Protein Phosphatase 1 Regulatory Inhibitor Subunit 16b Ankyrin Repeat Domain-Containing Protein 4 Caax Box Protein Timap Tgf-Beta-Inhibited Membrane-Associated Protein Htimap |
| Cellular Localisation | Cell Membrane Lipid-Anchor Nucleus Cell Projection Colocalizes With Rpsa/Lamr1 In The Cell Membrane Localizes To The Perinuclear Region Colocalizes With Pten At The Tip Of Ec Projections |
| Alternative Antibody Names | Anti-Protein Phosphatase 1 Regulatory Inhibitor Subunit 16b antibody Anti-Ankyrin Repeat Domain-Containing Protein 4 antibody Anti-Caax Box Protein Timap antibody Anti-Tgf-Beta-Inhibited Membrane-Associated Protein antibody Anti-Htimap antibody Anti-PPP1R16B antibody Anti-ANKRD4 antibody Anti-KIAA0823 antibody |
Information sourced from Uniprot.org