| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein phosphatase 1 regulatory inhibitor subunit 16B (364-413 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPP1R16B |
| Gene ID: |
26051 |
| Uniprot ID: |
PP16B_HUMAN |
| Immunogen Region: |
364-413 aa |
| Specificity: |
TIMAP Polyclonal Antibody detects endogenous levels of TIMAP protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human PPP1R16B at the amino acid range 364-413 |
| Function | Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the dephosphorylation of EEF1A1. |
| Protein Name | Protein Phosphatase 1 Regulatory Inhibitor Subunit 16bAnkyrin Repeat Domain-Containing Protein 4Caax Box Protein TimapTgf-Beta-Inhibited Membrane-Associated ProteinHtimap |
| Cellular Localisation | Cell MembraneLipid-AnchorNucleusCell ProjectionColocalizes With Rpsa/Lamr1 In The Cell MembraneLocalizes To The Perinuclear RegionColocalizes With Pten At The Tip Of Ec Projections |
| Alternative Antibody Names | Anti-Protein Phosphatase 1 Regulatory Inhibitor Subunit 16b antibodyAnti-Ankyrin Repeat Domain-Containing Protein 4 antibodyAnti-Caax Box Protein Timap antibodyAnti-Tgf-Beta-Inhibited Membrane-Associated Protein antibodyAnti-Htimap antibodyAnti-PPP1R16B antibodyAnti-ANKRD4 antibodyAnti-KIAA0823 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
