| Tissue Specificity | Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. |
| Function | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Is involved in NF-kappa-B dependent negative regulation of inflammatory response. |
| Protein Name | Rela-Associated InhibitorInhibitor Of Aspp ProteinProtein IasppNfkb-Interacting Protein 1Ppp1r13b-Like Protein |
| Database Links | Reactome: R-HSA-6804759 |
| Cellular Localisation | CytoplasmNucleusPredominantly Cytoplasmic But Also Nuclear |
| Alternative Antibody Names | Anti-Rela-Associated Inhibitor antibodyAnti-Inhibitor Of Aspp Protein antibodyAnti-Protein Iaspp antibodyAnti-Nfkb-Interacting Protein 1 antibodyAnti-Ppp1r13b-Like Protein antibodyAnti-PPP1R13L antibodyAnti-IASPP antibodyAnti-NKIP1 antibodyAnti-PPP1R13BL antibodyAnti-RAI antibody |
Information sourced from Uniprot.org
