| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPP1R13L (589-828) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPP1R13L |
| Gene ID: |
10848 |
| Uniprot ID: |
IASPP_HUMAN |
| Immunogen Region: |
589-828 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 589-828 of human PPP1R13L (NP_006654.2). |
| Immunogen Sequence: |
PPPAPSQSSPPEQPQSMEMR SVLRKAGSPRKARRARLNPL VLLLDAALTGELEVVQQAVK EMNDPSQPNEEGITALHNAI CGANYSIVDFLITAGANVNS PDSHGWTPLHCAASCNDTVI CMALVQHGAAIFATTLSDGA TAFEKCDPYREGYADCATYL ADVEQSMGLMNSGAVYALWD YSAEFGDELSFREGESVTVL RRDGPEETDWWWAALHGQEG YVPRNYFGLFPRVKPQRSK |
| Tissue Specificity | Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. |
| Function | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. |
| Protein Name | Rela-Associated InhibitorInhibitor Of Aspp ProteinProtein IasppNfkb-Interacting Protein 1Ppp1r13b-Like Protein |
| Database Links | Reactome: R-HSA-6804759 |
| Cellular Localisation | CytoplasmNucleusPredominantly Cytoplasmic But Also Nuclear |
| Alternative Antibody Names | Anti-Rela-Associated Inhibitor antibodyAnti-Inhibitor Of Aspp Protein antibodyAnti-Protein Iaspp antibodyAnti-Nfkb-Interacting Protein 1 antibodyAnti-Ppp1r13b-Like Protein antibodyAnti-PPP1R13L antibodyAnti-IASPP antibodyAnti-NKIP1 antibodyAnti-PPP1R13BL antibodyAnti-RAI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
