Anti-PPME1 antibody (1-160) (STJ115061)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PPME1 (1-160) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPME1 |
| Gene ID | 51400 |
| Uniprot ID | PPME1_HUMAN |
| Immunogen Region | 1-160 |
| Immunogen Sequence | MSALEKSMHLGRLPSRPPLP GSGGSQSGAKMRMGPGRKRD FSPVPWSQYFESMEDVEVEN ETGKDTFRVYKSGSEGPVLL LLHGGGHSALSWAVFTAAII SRVQCRIVALDLRSHGETKV KNPEDLSAETMAKDVGNVVE AMYGDLPPPIMLIGHSMGGA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PPME1 (NP_057231.1). |
Additional Info
| Post Translational Modifications | Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1. |
| Function | Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. |
| Protein Name | Protein Phosphatase Methylesterase 1Pme-1 |
| Database Links | Reactome: R-HSA-69273 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Protein Phosphatase Methylesterase 1 antibodyAnti-Pme-1 antibodyAnti-PPME1 antibodyAnti-PME1 antibodyAnti-PP2593 antibodyAnti-PRO0750 antibody |
Information sourced from Uniprot.org