| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPME1 |
| Gene ID: | 51400 |
| Uniprot ID: | PPME1_HUMAN |
| Immunogen Region: | 1-160 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PPME1 (NP_057231.1). |
| Immunogen Sequence: | MSALEKSMHLGRLPSRPPLP GSGGSQSGAKMRMGPGRKRD FSPVPWSQYFESMEDVEVEN ETGKDTFRVYKSGSEGPVLL LLHGGGHSALSWAVFTAAII SRVQCRIVALDLRSHGETKV KNPEDLSAETMAKDVGNVVE AMYGDLPPPIMLIGHSMGGA |
| Post Translational Modifications | Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1. |
| Function | Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. |
| Protein Name | Protein Phosphatase Methylesterase 1Pme-1 |
| Database Links | Reactome: R-HSA-69273 |
| Alternative Antibody Names | Anti-Protein Phosphatase Methylesterase 1 antibodyAnti-Pme-1 antibodyAnti-PPME1 antibodyAnti-PME1 antibodyAnti-PP2593 antibodyAnti-PRO0750 antibody |
Information sourced from Uniprot.org